Genetics

What is ChROseq and how does it work

At the moment of writing this post, I’m sitting on the plane flying to Cornell. There I will learn a beautiful technique called Chromatin Run-On and Sequencing, or ChRO-seq. Thirteen hours of travel is getting to the point of breaking my soul – I have finished most of work I can comfortablely do with one screen on a samll laptop. So I decided to write down what I know so far about ChRO-seq in preparation for my upcoming training tomorrow.

Haplotype, LD, and Association Tests

Table of content Table of content What Are Haplotype and Linkage Disequilibrium (LD) Quantify LD Linkage Disequilibrium Coefficient ($D$): Standardized Linkage Disequilibrium Coefficient ($D’$) Correlation coefficient ($\gamma^2$) Now why do we care about LD and haplotype? LD is an indication of deviation from Hardy-Weinberg equilibrium. This is the first post of my QE prep series. I’ll be taking notes on my study for general knowledge section of my QE.